![]() ![]() To facilitate the targeted therapy for OSMF, we carried out the structure-assisted screening of existing small molecules to target TGF- β1. Due to functional importance of this TGF- β1 signaling, TGF- β1 is proposed as a potent therapeutic target for the development of anti-OSMF drugs. It has been reported that areca nut chewing regulates TGF- β1 signaling in epithelial cells, which in turn affects the nearby fibroblasts leading canonical downstream SMAD signaling activation that results in mesenchymal interaction leading to fibrosis. Therefore, the search for effective anti-OSMF agents still continues. Many treatment modalities for OSMF have been proposed, but none has shown any significant effect so far. Studies indicated that near about 10% OSMF cases are associated with malignant transformation to oral squamous cell carcinoma (OSCC). Epidemiological evidences reflect exponential increase in OSMF in younger male population. Areca nut chewing has been reported the most probable cause of OSMF. Activation of transforming growth factor beta (TGF- β) signaling has been reported to lead increased collagen production, and fibrosis and significant upregulation of TGF- β1 have been reported in OSMF as compared to normal tissues. Submucosal fibrosis usually affects oral cavity, pharynx, and esophagus leading to dysphagia and progressive trismus and increases the risk for development of cancer. Oral submucous fibrosis (OSMF) is considered a premalignant condition characterized by aggressive fibrosis of the submucosal tissues of the oral cavity reflecting its malignant transformation potential. We suggest that this molecule can be validated and implemented for the treatment of OSMF. Based on the structure-assisted drug designing, we found “silmitasertib” as potent inhibitor of TGF- β1. Therefore, inhibition of the TGF- β1 may pave for the development of therapeutics of OSMF. Recently, significant upregulation of TGF- β1 has been reported in OSMF as compared to normal tissues. Activation of transforming growth factor beta (TGF- β) signaling has been reported to lead increased collagen production and fibrosis. ![]() ![]()
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